崔晋龙
姓名：崔晋龙
职称：教授
联系方式：E-mail：CJL717@sxu.edu.cn 微信号：CuiJL717
个人简介：崔晋龙，男，博士，山西大学应用化学研究所教授，山西大学中医药现代研究中心博（硕）导。研究方向：微生物与生化药学、中药品质的调控与质量控制、中草药化学与代谢组学等。任中国民族医药学会常务理事、山西省科协首席科学传播专家、山西省微生物学会常务理事、中国中药协会中药发酵药物委员会委员、山西省药理学会代谢组学分会常务理事等；《Ind. Crop. Prod.》、《Biotechnol. Adv.》、《J. Agric. Food Chem.》等杂志审稿人；主持国家自然科学基金、教育部博士点基金等10余项。获授权软著1项、国家发明专利8项；以第一作者或通讯作者在《Crit. Rev. Plant Sci.》、《Microb. Res.》、《J. Sci. Food Agr.》等发表文章80余篇。参编著作《新编中药材学》（黄璐琦，屠鹏飞主编）、《绿药觅踪》（肖培根主编）二部。
学习与工作经历：
2019/5－至今，山西大学，中医药现代研究中心，博士生导师
2011/7－2018.12，山西大学，应用化学研究所，教授
2015/10－2016/11，The Ohio State University（美），访问学者
2008/09－2011/07，清华大学&北京协和医学院，生药学，博士
2005/09－2008/07，首都师范大学，生命科学学院，微生物学，硕士
2001/07－2005/09，太原工业学院，生物工程系，生化制药室主任
1997/09－2001/07，山西大学，生命科学学院，生物化学，学士
工作职责：支部委员，科研与教学等
研究方向：微生物与生化药学、中药品质的调控与质量控制、中草药化学与代谢组学
讲授课程：微生物药物学
主持科研项目：
1、国家自然科学基金面上项目（32470419）：内生真菌对草麻黄茎与根差异代谢物积累的影响机理，50万，2025.01-2028.12，主持。
2、中央本级重大增减支项目：名贵中药资源可持续利用能力建设项目（2060302），20万，2023.7.1-2025.12.31，主持。
3、山西省基础研究计划（20210302123428）：内生菌对草麻黄代谢物质形成的生物学活性，10.00万元，2022.01-2024.12，主持。
4、国家自然科学基金面上项目（31670328）：锁阳-白刺寄生发育的内生真菌生态演替及与锁阳代谢的关联性研究， 61万，2017.01-2020.12，主持。
5、山西省卫生健康委的2025-2026年度中医药科研课题（储备）项目：山西道地黄芪内生真菌微生态演替特征及防控病害研究（2025ZYYA021），5.0万，2025.12.1-2028.11. 30，主持。
6、山西省留学回国基金（2020-013）：内生真菌对晋产道地黄芪品质的影响，4万，2020.8.1-2023.7.31，主持。
7、国家自然科学基金面上项目（31270383）：内生真菌对红景天活性成分积累的影响规律及机制研究，76万，2013.1-2016.12，主持。
8、山西省自然科学基金项目（2014011029-1）：红景天内生真菌遗传特征及抗氧化功能专属关系，3万， 2014.1-2016.12，主持。
9、高等学校博士学科点专项科研基金资助课题（20121401120001）：内生真菌诱导红景天活性成分积累的规律及机制研究，4万，2013.1-2015.12，主持。
10、山西省2022年度留学人员科技活动择优资助项目（20220004）：晋北特有植物麻黄内生真菌分子特征及其对宿主品质的影响，5.00万元，2022.1-2024.12，主持。
11、山西省研究生教育改革课题（2019JG018）:交叉学科中导师团队协同培养创新型研究生体系的探索与构建，2万，2019.6-2021.6，主持。
12、国家自然科学基金青年基金项目（31601677）：红蓼抗马铃薯环腐病菌天然先导化合物的发掘及其基于脂质体模型的作用方式研究，20万，2017.1-2019.12，第二参与。
13、山西省基础研究计划（202103021224029）：基于LC-MS非靶向代谢组学和RT-qPCR联用挖掘黄酮类黄芪抗根腐病相关代谢物，8万，2022.1-2024.12，第二参与。
14、山西省科技攻关项目（2014ZD0501-2）：黄芪根腐病专用微生物农药创制物质基础的筛选和评价，12万，2015.7-2017.12，第二参与。
15、国家科技重大专项（2021YFD19011105-2）：有机旱作农业新产品新装备研发与应用，167万；2021.12-2025.12，参与。
16、山西省科技重大专项（202101140601026-8）：低成本生物有机肥研发及应用，80万；2022.3-2025.12，参与。
17、山西省基础研究计划（202103021224017）： Z-3-己烯醛介导黄芪三萜皂苷合成积累作用及其机制研究，9万，2022.1-2024.12，第二参与。
代表性论文：
1. Shan-Shan Wang, Xin Ji, Jun-Hong Wang, Yuan-Peng-Hao*, Jin-Long Cui**. The characteristics of metabolites accumulation and their connections with endophytic fungi in roots and stems of Ephedra sinica with different cultivation ages. Fungal Biology. 2026, 130:101731.
2. Zhong-Ya Zhou, Xi Liu, Fen Gao, Meng-Liang Wang, Jun-Hong Wang, Jin-Long Cui*. Composition characterization of the culturable endophytic fungi in roots and their antagonistic activity against root rot of Astragalus mongholicus. Archives of Microbiology. 2026, 208(178):1-14.
3. Xiao-Ke Li, Ye Xia, Xue-Mei Qin, Jin-Long Cui *. Metabolic characteristics and identification of antidepressant functional ingredients and their pharmacological mechanisms during the development of flower buds in Hemerocallis citrina. Plant Physiol. Bioch., 2025, 226: 110056.
4. Shan Jiang, Jin-Long Cui*. miRNA TF gene regulatory network in metabolite differentiation of stem and root parts in Ephedra sinica Stapf. Plant Growth Regul., 2025, 105(2): 479-495.
5. Xiao Xing Wei, Hai-Xia Zhao, Jin-Long Cui*. Endophyte is an effective supplement to traditional factors affecting plant seed germination and its mechanism research progress. Russ. J. Plant Physiol., 2025, 72(2): 43.
6. Ding-Hui Feng, Jin-Long Cui*. The effect of endophytic fungus CA3-A with biotransformation or catalysis activity on the metabolite formation of traditional Chinese medicinal Astragalus membranaceus var. mongholicus (Bunge) P. K. Hsiao. Plant Foods Hum. Nutr., 2025, 80(1):69.
7. Ding-Hui Feng, Jin-Long Cui*. Progress on metabolites of Astragalus medicinal plants and a new factor affecting their formation: Biotransformation of endophytic fungi. Arch. Pharm. 2024; e2400249.
8. Xiao-Ke Li, Xue-Mei Qin, Jin-Long Cui*. Transcriptional regulatory mechanisms of flavonoid metabolism from flower bud to flower in Hemerocallis citrina. Sci. Hortic. 2024, 326: 112766.
9. Xi Liu, Jin-Long Cui*, Zhong-Ya Zhou, Zong-Bao Zhang, Xuan-Ge Cui, Bo Han, Jun-Hong Wang, Meng-Liang Wang, Yi-Min Li*.“Mini-community” simulation revealed the differences of endophytic fungal communities between the above- and below-ground tissues of Ephedra sinica Stapf. Fungal Biol., 2023, 127:1276-1283.
10. Hui Zhang, Ye Xia, Jin-Long Cui*, Xin Ji, Shuang-Man Miao, Gang Zhang, Yi-Min Li. The composition characteristics of endophytic communities and their relationship with metabolites profile in Ephedra sinica under wild and cultivated conditions. Environ. Sci. Pollut. R., 2023, 30: 95648-95659.
11. Xiao-Ke Li, Jin-Long Cui*, Xue-Mei Qin, Jun-Hong Wang, Meng-Liang Wang. Metabolic and transcriptional regulatory mechanisms of differential carbohydrates formation from flower buds to flowers of Hemerocallis citrina. Sci. Hortic. 2023, 308:111553.
12. Shuang-Man Miao, Ye Xia, Jin-Long Cui*，Jun-Hong Wang，Meng-Liang Wang. Correlation analysis between differential metabolites and endophytes of Ephedra sinica in different years. Ind. Crop. Prod. 2022,175: 114250.
13. Xin Ji, Ye Xia, Hui Zhang, Jin-Long Cui*. The microscopic mechanism between endophytic fungi and host plants: From recognition to building stable mutually beneficial relationships. Microbiol. Res. 2022, 261(127056):1-11.
14. Zhang-Xuan Guo#, Xiao-Ke Li#, Jin-Long Cui*, Shuang-Man Miao, Meng-Liang Wang, Jun-Hong Wang, Muhammad Danial.Transcriptional regulatory mechanism of differential metabolite formation in root and stem of Ephedra sinica. Appl. Biochem. Biotech. 2022, 194: 5506-5521.
15. Zhong-Ya Zhou, Xi Liu, Jin-Long Cui*, Jun-Hong Wang, Meng-Liang Wang, Gang Zhang*. Endophytic fungi and their bioactive secondary metabolites in medicinal leguminosae plants: nearly untapped medical resource. FEMS Microbiol. Lett. 2022, 369(1):1-14.
16. Shan Jiang, Jin-Long Cui*, Xiao-ke Li. MicroRNA-mediated gene regulation of secondary metabolism in medicinal plants. Crit. Rev. Plant Sci. 2021, 40(6): 459-478.
17. Xiaoke Li, Shan Jiang, Jinlong Cui*, Xuemei Qin，Gang Zhang. Progress of genus Hemerocallis in traditional uses, phytochemistry, and pharmacology. J. Hortic. Sci. Biotech. 2022, 97(3):298-314.
18. Xi Liu, Zhong-Ya Zhou, Jin-Long Cui*, Meng-Liang Wang, Jun-Hong Wang. Biotransformation ability of endophytic fungi: from species evolution to industrial applications. Appl. Microbiol. Biot. 2021, 105: 7095-7113.
19. Shuang-Man Miao#, Yan-Yan Zhang#, Jin-Long Cui*, Gang Zhang*. Species and geographic specificity between endophytic fungi and host supported by parasitic Cynomorium songaricum and its host Nitraria tangutorum distributed in desert. Arch. Microbiol., 2021, Doi: 10.1007/s0 0203-021-02224-7.
20. Xiao-zan Xue, Qi Zhang, Xiao-bao Bi, Yi Gong, Meng-liang Wang, Jun-hong Wang, Jin-long Cui*. NMR and UPLC-QTOF/MS-based metabolomics of different developmental stages of Cynomorium songaricum. Ital. J. Food Sci., 2020, 32: 997-1017.
21. Jin-Long Cui*, Xiao-Yin Gao, Vinod Vijayakumar, Zhang-Xuan Guo, Meng-Liang Wang*, Jun-Hong Wanga and Lei Liu. Regulation of fungal endophyte on Rhodiola crenulata from enzyme genes to metabolites based on combination of transcriptome and metabolome. J. Sci. Food Agr., 2020, 100: 4483–4494.
22. Qi Zhang, Xiao-Zan Xue, Shuang-Man Miao, Jin-Long Cui*, Xue-Mei Qin. Differential relationship of fungal endophytic communities and metabolic profiling between stems and roots from Ephedra sinica based on metagenomics and metabolomics. Symbiosis. 2020, 81(2):115-125.
23. Shuang-Man Miao, Qi Zhang, Xiao-bao Bi, Jin-Long Cui*, Meng-Liang Wang, Jun-Hong Wang. A review of the phytochemistry and pharmacological activities of Ephedra herb. Chin. J. Nat. Med. 2020, 18(5): 1-24.
24. Jin-Long Cui, Yi Gong, Vinod Vijayakumar, Gang Zhang, Meng-Liang Wang, Jun-Hong Wang and Xiao-Zan Xue. Correlation in chemical metabolome and endophytic mycobiome in Cynomorium songaricum from different desert locations in China. J. Agric. Food Chem. 2019, 67(13): 3554-3564.
25. Jin-Long Cui, Yan-Yan Zhang, Vinod Vijayakumar, Gang Zhang, Meng-Liang Wang, Jun-Hong Wang. Secondary metabolite accumulation associates with ecological succession of endophytic fungi in Cynomorium songaricum. J. Agric. Food Chem. 2018, 66(22):5499-5509.
26. Jin-Long Cui, Vinod Vijayakumar, Gan Zhang. Partitioning of fungal endophyte assemblages in root-parasitic plant Cynomorium songaricum and its host Nitraria tangutorum. Front. Microbiol., 2018, 9:666.
27. Jin-Long Cui, Yi Gong, Xiao-Zan Xue, Meng-Liang Wang, Junhong Wang. A phytochemical and pharmacological review on Cynomorium songaricum Rupr. as functional and medicinal food. Nat. prod. Commun, 2018,13(4):501-510.
28. Jin-Long Cui, Ya-Nan Wang, Jin Jiao, Yi Gong, Jun-Hong Wang, Meng-Liang Wang*. Fungal endophyte-induced salidroside and tyrosol biosynthesis combined with signal cross-talk and the mechanism of enzyme gene expression in Rhodiola crenulata. Sci. Rep., 2017, 7: 12540 DOI:10.1038/s41598-017-12895-2.
29. Jin-Long Cui, Tingting Guo, Jianbin Chao, Mengliang Wang, Junhong Wang. Potential of the Endophytic fungus Phialocephala fortinii Rac56 found in Rhodiola plants to produce salidroside and p-Tyrosol. Molecules. 2016, 21(4), 502; doi:10.3390/molecules21040502
30. Jin-Long Cui, Tingting Guo, Zhenxing Ren, Nasha Zhang, Mengliang Wang. Diversity and antioxidant activity of culturable endophytic fungi from alpine plants of Rhodiola crenulata, R. angusta, and R. sachalinensis. Plos one. 2015, 10(3):e0118204.doi:10.1371/journal. pone.0118204.
31. Jin-Long Cui, Li Fan*，Shaobin Fu，Mengliang Wang，Nasha Zhang，Tingting Guo. Inhibiting the growth of pathogenic microorganisms and producing flavonoids from endophytic fungi associated with Scutellaria baicalensis. Minerva. Biotecnol., 2014, 26(4): 215-221.
32. Jin-Long Cui, ChunLan Wang, ShunXing Guo *, PeiGen Xiaoa, MengLiang Wang. Stimulation of dragon’s blood accumulation in Dracaena cambodiana via fungal inoculation. Fitoterapia, 2013, 87: 31-36.
33. Jin-Long Cui, Chunlan Wang, Shunxing Guo, Lin Yang, Peigen Xiao, Mengliang Wang. Evaluation of fungus-induced agilawood from Aquilaria sinensis in China. Symbiosis, 2013, 60: 37-44.
34. Jin-Long Cui, ShunXing Guo*, Shaobin Fu, PeiGen Xiao, Mengliang Wang. Effects of inoculating fungi on agilawood formation in Aquilaria sinensis. Chinese Sci. Bull., 2013, 58(26): 3280-3287
35. Jin-Long Cui, ShunXing Guo*, PeiGen Xiao. Antitumor and antimicrobial activities of endophytic fungi from the medicinal parts of Aquilaria sinensis. J. zhejiang Univ. sci. B., 2011,12(5): 385-392.
36. Jin-Long Cui, Shunxing Guo*, Hailing Dong, Peigen Xiao. Endophytic fungi from dragon′s blood specimen: isolation, identification, phylogenetic diversity and bioactivity. Phytother. Res., 2011, 25:1189-1195.
37. Jin-Long Cui, Yunqiang Wang, Yongmei Xing, Shunxing Guo, Peigen Xiao, Mengliang Wang. Antimicrobial activity of endophytic fungi isolated from Dendrobium species in Southwestern China. Chin. J. Chin. Mater. Med., 2012, 37(6): 764-770.
38. Shaobin Fu, Junshan Yang, Jinlong Cui, Di-an Sun. Biotransformation of ursolic acid by Syncephalastrum racemosum CGMCC 3.2500 and anti-HCV activity. Fitoterapia. 2013，86：123-128.
39. Yongmei Xing, Juan Chen, Jinlong Cui, Shunxing Guo*. Antimicrobial activity and biodiversity of endophytic fungi in Dendrobium devonianum and Dendrobium thyrsiflorum from Vietman. Curr. Microbiol., 2011.62:1218-1224.
40. Yali Lv, Fusheng Zhang, Juan Chen, Jinlong Cui, Yongmei Xing, Xiangdong Li, and Shunxing Guo*. Diversity and antimicrobial activity of endophytic fungi associated with the alpine plant Saussurea involucrata. Biol. Pharm. Bull., 2010, 33(8): 1300-1306.
授权专利：
1. 崔晋龙，李晓科，秦雪梅.黄花菜中黄酮的提取方法和提取装置. 授权公告日： 2022.4.5,专利号：ZL202110989600.5.
2. 崔晋龙，张艳艳.利用真菌促进锁阳种子萌发的方法. 授权公告日： 2020.9.29, 专利号：201710842009.0
3. 崔晋龙，王雅楠，王梦亮. 双内参基因检测红景天苷合成酶基因表达活性的方法. 授权公告日：2019.6.28，专利号：CN201610316147.0
4. 崔晋龙，焦晋，王梦亮. 促进大花红景天积累红景天苷的真菌菌株及其应用。国家发明专利，授权公告日：2018.8.8，专利号：ZL 201610011872.7
5. 崔晋龙，王梦亮. 提高红景天组培苗中红景天苷和酪醇含量的方法。国家发明专利，授权时间：2016.9.28，专利号：ZL 201410468041.3
6. 崔晋龙，王梦亮. 利用红松头霉菌生产红景天苷和酪醇的方法. 国家发明专利，授权公告日：2017.4.26，专利号：ZL201410720396.7
7. 郭顺星，崔晋龙，陈晓梅，王春兰，孟志霞. 诱导龙血树产生血竭的2株真菌，国家发明专利，授权时间：2013.5.29，专利号：ZL 201110044300.6.
8. 郭顺星，崔晋龙，陈晓梅，王春兰，孟志霞. 诱导白木香产生沉香的3株真菌，国家发明专利，授权时间：2013.8.28，专利号：ZL 201110044325.6
软件著作
1．蒋珊，崔晋龙，蒋成.叶绿体基因分析软件V1.0（cpDNAAP），计算机软件著作，中国版权保护中心登记号：2022SR0218422.证书号：9172621.批准时间：2022.2.11。
参编主要著作
1、《绿药觅踪》肖培根等，中国医药科技出版社，2011.
2、《新编中国药材学》（第三卷）黄璐琦，屠鹏飞等，中国医药科技出版社，2020.
