李英奇
姓名：李英奇
职称：教授，博士生导师
联系方式：wkyqli@sxu.edu.cn
介绍：
中国化学会高级会员，曾获山西省模范教师，山西省教授协会“山西省高校师德楷模”。曾赴台湾中央研究院原子与分子科学研究所作博士后；获国家留学基金委资助赴加拿大温莎大学访学。
主要从事纳米材料的功能化及其在生物成像和靶向抗肿瘤效应以及在生物分子等检测方面的研究；金属离子与具有生物功能蛋白之间的作用。先后主持国家自然科学基金面上项目和省部级项目10余项；在Int. J. Biol. Macromol.，Talanta, Small, Int. J. Pharm., ACS Appl. Nano Mater等国际国内重要学术刊物和会议上发表学术论文100余篇；授权国家发明专利16项；获山西省自然科学奖二等奖2项；主持山西省教改项目2项；曾指导1名硕士研究生获山西省优秀硕士学位论文与国家奖学金，1名博士研究生获校级优秀博士学位论文；作为第一指导教师指导学生获第四届全国大学生化学实验创新设计大赛西北赛区一等奖（2023年），第五届全国大学生化学实验创新设计大赛国家二等奖和西北赛区一等奖（2025年）。为国际期刊Small, ACS Applied Materials & Interfaces，Analytical Chemistry，Current Drug Delivery等期刊审稿。
学习与工作经历：
2001年7月至今在PA电子从事教学和科研工作，一直致力于对功能化纳米材料的表面构建及其抗肿瘤效应、纳米团簇在生物分子的检测及肿瘤细胞识别中的应用等方面的研究工作。2003年9月至2006年7月在山西大学分子科学研究所读博士，获博士学位。2007年11月至2008年10月，在台湾中央研究院博士后工作。2019年9月至2020年9月在加拿大温莎大学做访问学者。
讲授课程：结构化学，结构化学实验
研究方向：从事化学与生物学交叉领域，属于物理化学/无机化学/制药工程专业，研究方向主要包括：
（1）功能化纳米材料及生物效应研究。
（2）纳米材料用于生物传感研究
获得奖励
1. 李英奇（1/4）排名第一，可控释放纳米钻石药物系统及靶向抗肿瘤效应研究，山西省人民政府，山西省科学技术奖（自然科学类），二等奖，2024年3月
2. 李英奇（6/6）排名第六，蝎神经毒素的活性分析及应用，山西省科学技术奖励委员会，山西省科学技术奖（自然科学类），二等奖，2019年3月
主持科研项目：
1. 山西省科技合作交流专项项目（重点国别科技合作），肿瘤微环境激活荧光/磁共振双模态导航的纳米钻石平台用于精准协同治疗肿瘤的研究，2025-01至2027-12
2. 山西省自然科学基金项目，可控光敏剂Ce6启动光动力的纳米钻石体系构建及抗肿瘤效应研究，2023-01至2025-12
3. 山西省专利转化专项计划项目，2023-04至2024-03
4. 山西省科学技术协会2023年全国科普日重点活动项目
5. 科技部专项基金项目，研发靶向和双开关型纳米钻石药物-乳腺癌“狙击手”的技术创兴平台，2019-01至2021-12
6. 山西省重点研发项目（社会发展），GSH调控的纳米钻石药物体系对肿瘤诊疗一体化研究，2019-12至2021-12
7. 山西省重点研发项目（社会发展），2016年中西药优化与应用研究-多功能纳米钻石药物的开发及其高效治疗肿瘤的应用，2016-07至2018-12
8. 山西省仪器设备购置及升级改造专项基金，2014.1-12
9. 山西省重点研发项目，恶性肿瘤发病机制及生物治疗的研究-荧光纳米钻石的肿瘤靶向检测和抗肿瘤活性研究，2013-01至2015-12
10. 国家自然科学基金面上项目，靶向和缓释双功能抗癌纳米钻石材料的制备及其生物效应研究，2010-01至2013-12
11. 山西省回国留学人员科研资助项目，具有靶向抗癌功能纳米钻石材料的制备及其生物效应研究，2010-01至2012-12
12. 山西省自然科学基金面上项目，2009011012-3，转铁蛋白纳米靶向载药系统制备及细胞内转运机理研究，2009-01至2012-12
13. 山西省自然科学青年基金，新型抗癌剂Ga（III）－铁传递蛋白与肝癌细胞的作用机制，2005-06-2007-12
代表性论文：
1. Xiaorui Dong, Wenjun Yan*, Dongmei Zhang, Xiuqing Dong*, Yingqi Li*, Biomass spinach-drived metal-free carbon dots-based nanozyme for multimodal nitrite sensing and functionalized by glucose oxidase as ROS amplifiers to enhance tumor therapy. Int. J. Biol. Macromol., 2025, 304, 140875.
2. Wenxia Zhang , Hui Qiao , Jicheng Cui , Dongmei Zhang*, Yingqi Li*, The redox homeostasis-reshapable hyaluronic acid-drug conjugate augments chemo-photodynamic therapy. Int. J. Biol. Macromol., 2025, 310, 143465.
3. Haotian Li, Yupeng Wang, Hui Qiao, Fengming Liu, Zhuoyu Li, Zhiqiang Han, Zhihua Guo, Yingqi Li*, Mingqiang Qiao*, A self-assembled fusion hydrophobin-coated nanodiamond system for synergistic targeted therapy of colorectal cancer. Chem. Commun. 2025,61,8075.
4. Chen Wang , Jicheng Cui , Yiqing He , Yingqi Li* , Yuejun Fu*，A novel ND-PAH/miR-34-5p inhibitor system regulates baculovirus infection by targeting SfEcR and SfE74 in Spodoptera frugiperda，Pestic. Biochem. Phys.，2025, 215, 106669
5. Hui Qiao, Wenxia Zhang, Dongmei Zhang, WenjunYan, Jianguo Li*, Yingqi Li*，Cu2+-mediated cascade-responsive nanodiamond-based platform triggering redox dyshomeostasis for cancer-specific chemo/ chemodynamic combination Therapy. ACS Appl. Nano Mater, 2025, 8, 3646–3660.
6. Hui Qiao, Jiangtao Wu, Dongmei Zhang*, Jicheng Cui, Wenxia Zhang, Yingqi Li*，Engineering nanodiamond platform for tumor light up and highperformance cancer treatment. Particuology, 2025, 99, 162-172.
7. Xiaorui Dong, Wenjun Yan*, dongmei Zhang, Ruihan Wang, Liuyan Xue, Heping Shi*, Yingqi Li*, Dual-emission fluorescent carbon dots for polarity/targeting bimodal recognition and mild photothermal therapy of tumor, Talanta, 2025, 282, 127060- 127069.
8. Ruihan Wang, Liuyan Xue, Xiaorui Dong, Wenjun Yan, Yingqi Li*, Chitosan-initiated gold nanoparticles with enhanced fluorescence for unique Fe3+/PPi sensing and photothermal therapy. Talanta, 2024, 271, 125719-125728.
9. Jicheng Cui, Dongmei Zhang*, Hui Qiao, Zeyu Yan, Wenxia Zhang, Yingqi Li*, MnO2-coated nanodiamond- driven photodynamic therapy for enhanced antitumor effect by addressing hypoxia and glutathione depletion. Particuology, 2024, 92, 305-315. (Cover）
10. Jiangtao Wu , Xiangbin Du , Dongmei Zhang , Jicheng Cui , Xiaoxia Zhang , Xine Duan, John F. Trant* , Yingqi Li*, A nanodiamond chemotherapeutic folate receptor-targeting prodrug with triggerable drug release, Int. J. Pharm., 2023, 630, 122432-122444. 11. Wenyan Li , Xingzhuo Zhou , Wenjun Yan , Ruihan Wang , Zeqian Yang , Yongchong Hu , Yang Liu, Zhichao Jia , Yingqi Li*, Lysozyme-encapsulated gold nanoclusters for ultrasensitive detection of folic acid and in vivo imaging, Talanta, 2023, 251, 123789-123798.
12. Wenyan Li , Ruihan Wang , Zeqian Yang , Xingzhuo Zhou , Wenjun Yan , Yingqi Li*, A copper ion-mediated on-off-on gold nanocluster for pyrophosphate sensing and bioimaging in cells, Anal. Chim. Acta, 2023, 1249, 340923-340931.
13. Jicheng Cui, Wenjing Zhao, Jiangtao Wu, Dongmei Zhang, Longguang Liu , Hui Qiao , Zeyu Yan , Yuejun Fu , John F. Trant,* Yingqi Li*，Enhanced in vivo antitumor efficacy through the nanodiamond mediated co-delivery of drugs，J. Drug Deli.Sci. Tec., 2023, 88 ,104984-104992.
14. Jicheng Cui, Bo Hu, Yuejun, Zhengkun Xu, Yingqi Li*, pH-Sensitive nanodiamond co-delivery of retinal and doxorubicin boosts breast cancer chemotherapy, RSC Adv., 2023, 13, 27403–27414.
15. Xiangping Wen, Guangming Wen, Wenyan Li, Zhonghua Zhao, Xine Duan*, Wenjun Yan, John F. Trant*, Yingqi Li*，Carbon dots for specific “off-on” sensing of Co2+ and EDTA for in vivo bioimaging, Mat. Sci. Eng. C，2021, 123, 112022-112033.
16. Wenyan Li, Xiangping Wen, Hemiao Zhao, Wenjun Yan, John F. Trant*, Yingqi Li*, Acid-Triggered Self-Assembled Egg White Protein-Coated Gold Nanoclusters for Selective Fluorescent Detection of Fe3+, NO2−, and Cysteine, ACS Appl. Nano Mater. 2020, 3, 11838-11849.
17. Xiangbin Du, Lin Li, Shiguo Wei, Songbai Wang, Yingqi Li*, A tumor-targeted, intracellular activatable and theranostic nanodiamond drug platform for strongly enhanced in vivo antitumor therapy, J. Mater. Chem. B，2020, 8, 1660.
18. Xiangping Wen, Zhonghua Zhao, Shuqin Zhai, Xiedong Wang, Yingqi Li*, Stable nitrogen and sulfur co-doped carbon dots for selective folate sensing, in vivo imaging and drug delivery, Diam. Relat. Mater., 2020, 105, 107791.
19. Shiguo Wei; Lin Li; Xiangbin Du; Yingqi Li *; OFF–ON nanodiamond drug platform for targeted cancer imaging and therapy, J. Mater. Chem. B, 2019, 7, 3390.
20. Hemiao Zhao; Xiangping Wen; Wenyan Li; Yingqi Li *; Caixia Yin *; A copper-mediated on–off–on gold nanocluster for endogenous GSH sensing to drive cancer cell recognition, J. Mater. Chem. B,2019, 7, 2169.
21. Lu Tian, Wenjing Zhao, Lin Li, Yaoli Tong, Guanlin Peng, Yingqi Li*, Multi-talented applications for cell imaging, tumor cells recognition, patterning, staining and temperature sensing by using egg white-encapsulated gold nanoclusters, Sensor. Actuat. B-Chem. 2017, 240, 114.
22. Wenjing Zhao, Shiguo Wei, Hemiao Zhao, Yingqi Li*, Ruifang Wu, Juanjuan Wang, Enhanced anticancer activity of an intracellularly activatable nanomedicine based on GLYlated nanodiamond, Diam. Relat. Mater., 2017, 77, 171.
23. Lu Tian, Yangfan Li, Tingting Ren, Yaoli Tong, Binsheng Yang, Yingqi Li*, Novel bimetallic gold-silver nanoclusters with “synergy”-enhanced fluorescence for cyanide sensing, cell imaging and temperature sensing, Talanta, 2017, 170, 530.
24. Lin Li, Lu Tian, Yongli Wang, Wenjing Zhao, Fangqin Cheng, Yingqi Li*, Binsheng Yang*, Smart pH-responsive and high doxorubicin loading nanodiamond for in vivo selective targeting, imaging, and enhancement of anticancer therapy, J. Mater. Chem. B, 2016, 4, 5046.
25. Bin Liu, Xiangquan Hu, Jie Chai, Junyao Zhu, Binsheng Yang*, Yingqi Li*, Application of nanodiamonds in Cu(II)-based rhodamine B probes for NO detection and cell imaging, J. Mater. Chem. B, 2016, 4, 3358.
26. Lin Li, Lu Tian, Wenjing Zhao, Yingqi Li*, Binsheng Yang*, Acetate ions enhance load and stability of doxorubicin onto PEGylated nanodiamond for selective tumor intracellular controlled release and therapy, Integr. Biol., 2016, 8, 956.
27. Lin Li, Lu Tian, Wenjing Zhao, Fangqin Cheng, Yingqi Li*, Binsheng Yang*, pH-sensitive nanomedicine based on PEGylated nanodiamond for enhanced tumor therapy, RSC Adv., 2016, 6, 36407.
28. Yu Dong, Ruixia Cao, Yingqi Li*, Zhiqin Wang, Lin Li, Lu Tian, Folate-conjugated nanodiamond for tumor targeted drug delivery, RSC Adv., 2015, 5, 82711.
29. ZhiqinWang, Zhimei Tian, Yu Dong, Lin Li, Lu Tian, Yingqi Li*, Binsheng Yang, Nanodiamond-conjugated transferrin as chemotherapeutic drug delivery, Diam. Relat. Mater., 2015, 58, 84.
30. Yingqi Li*, Yaoli Tong, Ruixia Cao, Zhimei Tian, Binsheng Yang, Pin Yang, In vivo enhancement of anticancer therapy using bare or chemotherapeutic drug-bearing nanodiamond particles, Int. J. Nanomed., 2014, 9, 1065.
31. Dongxin Wang, Yingqi Li*, Ruixia Cao, Zhimei Tian, Binsheng Yang*, Transferrin-conjugated nanodiamond as intracellular transporter of chemotherapeutic drug and targeting therapy for Cancer Cells, Ther. Deliv., 2014, 5, 511.
32. Dongxin Wang, Yaoli Tong, Yingqi Li*, Zhimei Tian, Ruixia Cao, Binsheng Yang*, PEGylated nanodiamond for chemotherapeutic drug delivery, Diam. Relat. Mater., 2013, 36, 26.
33. Dongxin Wang, Yingqi Li*, Binsheng Yang*. Interaction between Fluorescent Nanodiamond and Human Transferrin and Intracellular Imaging. Acta Chim. Sinica，2013, 71, 782.
34. Yuejun Fu, Nan An, Shuhua, Zheng, Aihua Liang, Yingqi Li*, BmK CT-conjugated fluorescence nanodiamond as potential glioma-targeted imaging and drug, Diam. Relat. Mater., 2012, 21, 73.
35. Yingqi Li*, Xueping Zhou, Dongxing Wang, Binsheng Yang*, Pin Yang, Nanodiamond mediated delivery of chemotherapeutic drugs, J. Mater. Chem., 2011, 21, 16406.
36. Yingqi Li*, Xueping Zhou, Transferrin-coupled fluorescence nanodiamonds as targeting intracellular transporters: An investigation of the uptake mechanism, Diam. Relat. Mater., 2010, 19, 1163.
37. Yingqi Li*, Xueping Zhou, Xueying Ren，Xine Duan, Effect of Eu3+ on the conformation of apoovotransferrin，Acta Chim. Sinica, 2010, 68, 1027.
38. Yingqi Li，Bin Liu，Binsheng Yang*, Spectroscopic analysis of the interaction between chromium (III) and apoovotransferrin，J. Lumin.，2010，130, 2339.
授权专利：
1. 李英奇，崔继成，pH响应释药的双药纳米钻石药物及其制备方法和应用，ZL202211082924.1
2. 李英奇，周星灼，杨泽前，一种氮掺杂红色荧光碳点及其制备方法和应用，ZL202310721306.5
3. 李英奇，武江涛，杜祥斌，一种GSH响应型纳米钻石靶向药物及其制备方法和应用，ZL202010512739.6.
4. 李英奇，温香平，一种氮磷共掺杂荧光碳点及其制备方法和应用，ZL202010522580.6
5. 李英奇，赵鹤妙，一种H+改性的红色荧光金纳米团簇及其制备方法和应用，ZL201910281311.2
6. 李英奇，赵鹤妙，一种转铁蛋白为模板的金纳米团簇及其制备方法和应用，ZL201811580659.3
7. 李英奇，杜祥斌，一种复合纳米钻石药物及其制备方法和应用 ZL201810585170.9 1.
8. 李英奇，王志琴，一种磁靶向纳米钻石药物及其制备方法和应用，ZL201610067837.7.
9. 李林，李英奇，杨斌盛，高负载及pH可控释放阿霉素的纳米钻石药物制备和应用，ZL201510591826.4.
10. 李林，李英奇，杨斌盛，一种以腙键连接的纳米钻石药物及其制备方法和应用，ZL201510291034.5.
11. 李林，李英奇，杨斌盛，一种酯键偶联纳米钻石阿霉素药物及其制备方法和应，ZL201510291057.6
12. 李英奇，王青，李林，纳米钻石表面修饰负载甲氨蝶呤的药物及其制备方法， ZL201510005266.X.
13. 李英奇，董晓宇，叶酸修饰的纳米钻石靶向药物的制备方法和应用，ZL201410006838.1.
14. 李英奇，王东新，一种靶向纳米钻石载体和靶向药物及其制备方法和应用，ZL 201310124917.8
